Wild-type mice | Cx32-deficient mice | Difference (in %) | |
---|---|---|---|
Values given as mean ± SD; *significantly different at the 5% level; NS, not significant. | |||
aFor calculation see text. | |||
bNecessary to evoke a single action potential. | |||
Resting membrane potential (in mV, n = 24/30) | -85.21 ± 6.12 | -84.37 ± 5.90 | 1.0 (NS) |
Input resistance (in MΩ, n = 24/30) | 46.74 ± 14.98 | 59.57 ± 19.86 | 27.4* (P = 0.011) |
Membrane time constant τ0 (in ms, n = 24/29) | 9.36 ± 2.02 | 10.44 ± 3.39 | 11.5 (NS) |
First equalizing time constant τ1 (in ms, n = 24/29) | 1.67 ± 0.70 | 1.34 ± 1.50 | 19.8* (P = 0.047) |
Slope of IV curve at -0.2 nA (in MΩ, n = 9/11) | 39.61 ± 13.85 | 55.19 ± 10.54 | 28.2* ( P = 0.010) |
Slope of IV curve at +0.2 nA (in MΩ, n = 9/11) | 68.63 ± 30.19 | 100.10 ± 21.81 | 31.4* (P = 0.015) |
Rectification ratioa (n = 9/11) | 1.72 ± 0.33 | 1.84 ± 0.26 | 6.5 (NS) |
Threshold currentb (in nA, n = 17/21) | 0.53 ± 0.16 | 0.39 ± 0.15 | 26.4* (P = 0.006) |
Slope of steady-state f-I plot (in Hz/nA, n = 11/11) | 71.1 ± 16.4 | 93.3 ± 23.6 | 24.2* (P = 0.019) |
Article: Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Sutor B; Schmolke C; Teubner B; Schirmer C; Willecke K Cereb. Cortex, 2000
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | resting membrane potential | -85.21 ± 6.12 (24) | -85.21 (mV) | Data Table |
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | input resistance | 46.74 ± 14.98 (24) | 46.74 (MΩ) | Data Table |
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | membrane time constant | 9.36 ± 2.02 (24) | 9.36 (ms) | Data Table |
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | membrane time constant | 1.67 ± 0.7 (24) | 1.67 (ms) | Data Table |
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | rheobase | 0.53 ± 0.16 (24) | -- | Data Table |
Neocortex pyramidal cell layer 2-3 | neocortical layer 2-3 regular spiking pyramidal cells | FI slope | 71.1 ± 16.4 (24) | 71.1 (Hz/nA) | Data Table |